Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model
Retinitis pigmentosa (RP) is an inherited retinal disease in which there is a loss of cone-
mediated daylight vision. As there are> 100 disease genes, our goal is to preserve cone …
mediated daylight vision. As there are> 100 disease genes, our goal is to preserve cone …
Retinal Disorders
Retinal disorders caused by genetic or environmental factors cause severe visual
impairment and often result in blindness. The past ten years have seen rapid progress in our …
impairment and often result in blindness. The past ten years have seen rapid progress in our …
[HTML][HTML] Oxidative Stress, Inflammation and Altered Glucose Metabolism Contribute to the Retinal Phenotype in the Choroideremia Zebrafish
C Méjécase, N Nair, H Sarkar, P Soro-Barrio, M Toms… - Antioxidants, 2024 - mdpi.com
Reactive oxygen species (ROS) within the retina play a key role in maintaining function and
cell survival. However, excessive ROS can lead to oxidative stress, inducing dysregulation …
cell survival. However, excessive ROS can lead to oxidative stress, inducing dysregulation …
[HTML][HTML] Bile acid metabolism changes in patients with a CRB1-IRD
L Moekotte, JH de Boer, S Hiddingh, B Gerritsen… - Ophthalmology …, 2025 - Elsevier
Purpose To compare the plasma metabolic profile of patients with a CRB1-associated
inherited retinal degeneration (CRB1-IRD) with healthy controls (HCs). Design A case …
inherited retinal degeneration (CRB1-IRD) with healthy controls (HCs). Design A case …
Cell type-focused compound screen in human organoids reveals molecules and pathways controlling cone photoreceptor death
SE Spirig, VJ Arteaga-Moreta, Z Raics… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Human organoids that mirror their corresponding organs in cell-type diversity
present an opportunity to perform large-scale screens for compounds that protect disease …
present an opportunity to perform large-scale screens for compounds that protect disease …