The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Acquired resistance inevitably limits the curative effects of epidermal growth factor receptor
tyrosine kinase inhibitors (EGFR-TKIs), which represent the classical paradigm of molecular …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

Gamma secretase inhibitors (GSIs), initially developed as Alzheimer's therapies, have been
repurposed as anticancer agents given their inhibition of Notch receptor cleavage. The …

Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or
fibroblasts. In general, they are slow growing and do not metastasize; however, locally …

Background Ovarian cancer has the highest ratio of mortality among gynecologic
malignancies. Chemotherapy is one of the most common treatment options for ovarian …

Abstract Background Deregulated Notch signaling due to mutation or overexpression of
ligands and/or receptors is implicated in various human malignancies. γ-Secretase inhibitors …