About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Adenosine modulates many aspects of human physiology and pathophysiology through
binding to the adenosine family of G protein-coupled receptors, which are comprised of four …

Several studies have demonstrated the expression of odorant receptors (OR) in various
human tissues and their involvement in different physiological and pathophysiological …

Background and Purpose Inhibition of the G‐protein gated ACh‐activated inward rectifier
potassium current, IK, ACh may be an effective atrial selective treatment strategy for atrial …

Pulmonary veins (PV) are the main source of ectopy, triggering atrial fibrillation. This study
investigated the roles of G protein-coupled inwardly rectifying potassium (GIRK) channels in …

Electrical remodelling as a result of homeodomain transcription factor 2 (Pitx2)-dependent
gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide …

Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to
developing innovative therapies that limit the onset and the progression of AF is to fully …

Background Adenosine leads to atrial action potential (AP) shortening through activation of
adenosine 1 receptors (A1-R) and subsequent opening of G-protein-coupled inwardly …

There is a clear unmet medical need for new pharmacologic therapies with improved
efficacy and safety for the treatment of atrial fibrillation. Considerable research efforts have …

Sympathetic and vagal activation is linked to atrial arrhythmogenesis. Here we investigated
the small conductance Ca2+-activated K+ (SK)-channel pore-blocker N-(pyridin-2-yl)-4 …