Atherosclerosis is an arterial disease process characterized by the focal subendothelial
accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells …

According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Dendritic cells (DCs), a type of professional antigen-presenting cells, are responsible for
initiation and maintenance of immune responses. Here we report that a substantial …

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for
16.7 million deaths each year. The underlying cause of the majority of CVD is …

Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with
increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) …

Both the chronic development of atherosclerotic lesions and the acute changes in lesion
phenotype that lead to clinical cardiovascular events are significantly influenced by the …

As an abundantly expressed cysteine protease inhibitor widely distributed in the organisms,
cystatin C is involved in various physiological processes. Due to its relatively small …

Immune mechanisms are known to control the pathogenesis of atherosclerosis. However,
the exact role of DCs, which are essential for priming of immune responses, remains elusive …

Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …