Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Studies on synaptic plasticity in the context of learning have been dominated by the view
that a single, particular type of plasticity forms the underlying mechanism for a particular type …

Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and
memory. Accumulating evidence suggests that glia participates in sculpting the neuronal …

Synaptic plasticity (eg, long-term potentiation [LTP]) is considered the cellular correlate of
learning. Recent optogenetic studies on memory engram formation assign a critical role in …

Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Although our ability to store semantic declarative information can nowadays be readily
surpassed by that of simple personal computers, our ability to learn and express procedural …

Three decades of electrophysiological research on cerebellar cortical activity underlying
Pavlovian conditioning have expanded our understanding of motor learning in the brain …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein
SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving …

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been
proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have …

Closed-loop circuitries between cortical and subcortical regions can facilitate precision of
output patterns, but the role of such networks in the cerebellum remains to be elucidated …