Introduction: Quinazoline and quinazolinone scaffolds represent an important class of
biologically active nitrogen heterocyclic compounds. A variety of marketed drugs are based …

Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

The most dangerous subtype of breast cancer, triple-negative breast cancer (TNBC),
accounts for 25% of all breast cancer-related deaths and 15% of all breast cancer cases …

During the last decade quinoline derivatives have been shown to be useful starting
materials and building blocks for the synthesis of a great variety of functionalized …

Background Sulfonamide derivatives are of great attention due to their wide spectrum of
biological activities. Sulfonamides conjugated with acetamide fragments exhibit …

A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1 H-1, 2, 4-triazol-5-amine
derivatives (7a–7r) were designed and synthesized based on a pharmacophore hybrid …

Privileged structures can bind to multiple targets with high affinity, thus aiding the discovery
of novel bioactive agents. Heterocycle-thioacetic acid derivatives, a group of molecules …

2‐Hydrazinyl‐N‐(4‐sulfamoylphenyl) acetamide 3 was the key intermediate for the
synthesis of novel hydrazones 4–10 and pyrazole derivatives 11–17. All compounds were …

The present study deals with the synthesis of N‐phenylacetamide‐functionalized carbazole
derivatives and their antibacterial, anti‐inflammatory, and antioxidant assays. In vitro …

Nowadays, the growth of drug-resistant microbial strains (MDRs) is a serious public health
threat worldwide. Moreover, tens of millions of people are annually diagnosed with cancer …