Regulation of stress response on the hypothalamic-pituitary-gonadal axis via gonadotropin-inhibitory hormone

YL Son, T Ubuka, K Tsutsui - Frontiers in Neuroendocrinology, 2022 - Elsevier
Under stressful condition, reproductive function is impaired due to the activation of various
components of the hypothalamic–pituitaryadrenal (HPA) axis, which can suppress the …

Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

T Ubuka, YL Son, K Tsutsui - General and comparative endocrinology, 2016 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that was isolated
from the brains of Japanese quail in 2000, which inhibited luteinizing hormone release from …

Hypothalamus as an endocrine organ

IJ Clarke - Comprehensive Physiology, 2011 - Wiley Online Library
The endocrine hypothalamus constitutes those cells which project to the median eminence
and secrete neurohormones into the hypophysial portal blood to act on cells of the anterior …

Central and peripheral neuropeptide RFRP-3: a bridge linking reproduction, nutrition, and stress response

P Singh, S Anjum, RK Srivastava, K Tsutsui… - Frontiers in …, 2022 - Elsevier
This article is an amalgamation of the current status of RFRP-3 (GnIH) in reproduction and
its association with the nutrition and stress-mediated changes in the reproductive activities …

GABAergic inputs to POMC neurons originating from the dorsomedial hypothalamus are regulated by energy state

AR Rau, ST Hentges - Journal of Neuroscience, 2019 - Soc Neuroscience
Neuronal circuits regulating hunger and satiety synthesize information encoding the energy
state of the animal and translate those signals into motivated behaviors to meet homeostatic …

Structural and functional divergence of gonadotropin-inhibitory hormone from jawless fish to mammals

S Ogawa, IS Parhar - Frontiers in Endocrinology, 2014 - frontiersin.org
Gonadotropin-inhibitory hormone (GnIH) was discovered as a novel hypothalamic peptide
that inhibits gonadotropin release in the quail. The presence of GnIH-homologous peptides …

Gonadotropin‐inhibitory hormone in the flatfish, Solea senegalensis: Molecular cloning, brain localization and physiological effects

M Aliaga‐Guerrero… - Journal of …, 2018 - Wiley Online Library
Recently, gonadotropin‐inhibitory hormone (GnIH) has emerged as an important regulator
of reproduction in birds and mammals. This RFamide neuropeptide has neuromodulatory …

Involvement of mammalian RF-amide peptides and their receptors in the modulation of nociception in rodents

S Ayachi, F Simonin - Frontiers in endocrinology, 2014 - frontiersin.org
Mammalian RF-amide peptides, which all share a conserved carboxyl-terminal Arg–Phe–
NH2 sequence, constitute a family of five groups of neuropeptides that are encoded by five …

Examination of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in development and adulthood

MC Poling, MP Shieh, N Munaganuru, E Luo… - …, 2015 - karger.com
Background: The neuropeptide RFamide-related peptide-3 (RFRP-3; mammalian ortholog
to gonadotropin-inhibiting hormone) can inhibit luteinizing hormone (LH) release and …

Dual actions of mammalian and piscine gonadotropin-inhibitory hormones, RFamide-related peptides and LPXRFamide peptides, in the hypothalamic–pituitary …

T Ubuka, I Parhar - Frontiers in Endocrinology, 2018 - frontiersin.org
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that decreases
gonadotropin synthesis and release by directly acting on the gonadotrope or by decreasing …