Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins
ANA Daud, JEH Bergman, MK Bakker, H Wang… - …, 2014 - Taylor & Francis
One of the ongoing issues in perinatal medicine is the risk of birth defects associated with
maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the …
maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the …
Polymorphisms of UGT1A9 and UGT2B7 influence the pharmacokinetics of mycophenolic acid after a single oral dose in healthy Chinese volunteers
Purpose To explore the impact of UDP-glucuronosyltransferase polymorphisms (UGT1A9-
118 (dT) 9/10, UGT1A9 CI399T, UGT1A9 C-440T and UGT2B7 G211T) on the …
118 (dT) 9/10, UGT1A9 CI399T, UGT1A9 C-440T and UGT2B7 G211T) on the …
Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese …
Y Lu, Y Fang, X Wu, C Ma, Y Wang, L Xu - European journal of clinical …, 2017 - Springer
Aim The human UDP-glucuronosyltransferase which is genetically polymorphic catalyzes
glucuronidations of various drugs. The interactions among UGT1A4, UGT1A6, UGT1A9, and …
glucuronidations of various drugs. The interactions among UGT1A4, UGT1A6, UGT1A9, and …
Regression and genomic analyses on the association between dose-normalized mycophenolic acid exposure and absolute neutrophil count in steroid-free, de novo …
TKL Kiang, N Partovi, RJ Shapiro, JM Berman… - Clinical drug …, 2018 - Springer
Abstract Background and Objectives The hematological side effects associated with
mycophenolic acid (MPA) are relatively common and have severe consequences. The …
mycophenolic acid (MPA) are relatively common and have severe consequences. The …
Influence of ABCC2, SLCO1B1, and ABCG2 polymorphisms on the pharmacokinetics of olmesartan
This study was designed to determine whether genetic polymorphisms of multidrug-resistant
protein 2 (ABCC2), organic anion transporting polypeptide 1B1 (SLCO1B1), and breast …
protein 2 (ABCC2), organic anion transporting polypeptide 1B1 (SLCO1B1), and breast …
MRP2 (ABCC2) and MRP3 (ABCC3)
AT Nies - … of Human Drug Transporters: Clinical Impacts, 2013 - Wiley Online Library
The human genome comprises 48 ATP-binding cassette (ABC) transporter genes. The 48
ABC proteins are grouped into seven subfamilies on the basis of amino acid sequence and …
ABC proteins are grouped into seven subfamilies on the basis of amino acid sequence and …
[HTML][HTML] Screening study for genetic polymorphisms affecting pharmacokinetics of simvastatin
S Im, BH Kim, K Lee, KB Kwack… - Translational and …, 2016 - synapse.koreamed.org
Simvastatin reduces plasma cholesterol by inhibiting HMG-CoA reductase (HMGR) and is
widely used in the treatment of hypercholesterolemia. To screening the possible genetic …
widely used in the treatment of hypercholesterolemia. To screening the possible genetic …
Investigation of the 1249G> A Genetic Variation of ABCC2 Drug Transporter Gene in the Turkish Population
ZU Sahinogullari - Dicle Tıp Dergisi, 2021 - dergipark.org.tr
Objectives: ATP binding cassette (ABC) transporters are a major superfamily of drug
transporters and provide active transport of diverse substrates across cell membranes of …
transporters and provide active transport of diverse substrates across cell membranes of …
No sex difference in overall P-glycoprotein activity as assessed by talinolol disposition in humans
B Long, S Yuan-qi, Y Xia, Z Yan-ye… - … Journal of Clinical …, 2016 - search.proquest.com
Purpose: The aim of this study was to investigate the sex-dependent difference in P-
glycoprotein activity as measured by the probe drug talinolol. Methods: A randomized, single …
glycoprotein activity as measured by the probe drug talinolol. Methods: A randomized, single …
[PDF][PDF] Funktionelle Analyse von ABCC2-Haplotypen
S Lächelt - 2009 - macau.uni-kiel.de
Die Wirksamkeit einer Arzneimitteltherapie ist abhängig vom komplexen Zusammenspiel
von verschiedenen Prozessen, die zur Verteilung und Antwort auf Arzneimittel führen …
von verschiedenen Prozessen, die zur Verteilung und Antwort auf Arzneimittel führen …