The innate immune system in drosophila and mammals senses the invasion of
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

Drosophila mounts a potent host defence when challenged by various microorganisms.
Analysis of this defence by molecular genetics has now provided a global picture of the …

The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria.
During the last two decades, significant progress has been made in identifying the …

Essential to the construction, maintenance and repair of tissues is the ability to induce
suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency …

The first proapoptotic caspase, CED-3, was cloned from Caenorhabditis elegans in 1993
and shown to be essential for the developmental death of all somatic cells. Following the …

Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …

Innate immunity is the first line of defense against infectious microorganisms. The innate
immune system relies on germ line-encoded pattern recognition receptors (PRRs) to …

The immune system provides protection from a wide range of pathogens. One component of
immunity, the phylogenetically ancient innate immune response, fights infections from the …

Flies respond to infection with both humoral and cellular immune defenses, including a
powerful set of inducible peptide antibiotics as well as actively proliferating and …