Transcription-factor-based biosensors (TFBs) are often used for metabolite detection,
adaptive evolution, and metabolic flux control. However, designing TFBs with superior …

Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

CO2 sequestration engineering is an attractive strategy for achieving carbon-and energy-
efficient bioproduction. However, the efficiency of heterotrophic CO2 sequestration is limited …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

Global warming and climate instability have spurred interest in using renewable carbon
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …

The demand for sustainable and environmentally friendly sources of foods and cosmetics is
increasing owing to concerns about the rapid growth of the global population and climate …

In industrial bioprocesses, microbial metabolism dictates the product yields, and therefore,
our capacity to control it has an enormous potential to help us move towards a bio-based …

Shikimic acid (SA), a hydroaromatic natural product, is used as a chiral precursor for organic
synthesis of oseltamivir (Tamiflu®, an antiviral drug). The process of microbial production of …

Metabolic engineering reprograms cells to synthesize value-added products. In doing so,
endogenous genes are altered and heterologous genes can be introduced to achieve the …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …