Drug addiction is a worldwide societal problem and public health burden, and results from
recreational drug use that develops into a complex brain disorder. The opioid system, one of …

Abstract Background and Aims There is wide inter‐individual variability in response to the
treatment of alcohol use disorder (AUD) with the opioid receptor antagonist naltrexone. To …

Background: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a
stimulus that has been associated with reward or punishment alters operant behaviour. In …

Substance use disorders (SUD) and behavioral addictions are devastating conditions that
impose a severe burden on all societies, and represent difficult challenges for clinicians …

Background: Opioids are widely used as an analgesic for the treatment of moderate to
severe pain. However, there are interindividual variabilities in opioid response. Current …

Background: Risk behaviors for young adults such as alcohol use are associated with
increased risk of morbidity and mortality. Patterns of risk behavior may be genetically …

Introduction To make early predictions of PACU VAS before surgery, we created a novel
nomogram for the early prediction of PACU VAS in patients having laparoscopic radical …

Objective We carried out a meta-analysis of four opioid and dopamine candidate gene
polymorphisms having conflicting results in prior literature, namely OPRM1 rs1799971, DAT …

Background Drugs are chemicals which can disrupt the nerve cell functions of the brain. The
present study aims to investigate the addiction related gene (OPRM1) in three types of …

Background and aims A single nucleotide polymorphism of A118G (SNP; rs1799971) in the
opioid receptor μ-1 (OPRM1) gene is a missense variant that influences the affinity of μ …