Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Metabolic and haemodynamic perturbations and their interaction drive the development of
diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD) …

Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in
the United States. Diabetic kidney disease is considered a proteinuric glomerular disease …

Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and developing countries. Diabetes affects all cell types of the kidney …

Renal inflammation is the initial, healthy response to renal injury. However, prolonged
inflammation promotes the fibrosis process, which leads to chronic pathology and eventually …

The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

Diabetic kidney disease remains a major microvascular complication of diabetes and the
most common cause of chronic kidney failure requiring dialysis in the United States. Medical …

Diabetic kidney disease (DKD) is the first cause of end-stage kidney disease in patients with
diabetes and its prevalence is increasing worldwide. It encompasses histological alterations …

Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease
(CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy …