Leukemia results from the accumulation of multiple genetic alterations that disrupt the
control mechanisms of normal growth and differentiation. The use of inbred mouse strains …

Mice homozygous for the recessive mutation vestigial tail (vt), which arose spontaneously on
Chromosome 11, exhibit vertebral abnormalities, including loss of caudal vertebrae leading …

Guinea pig eotaxin is a recently described member of the Cys-Cys family of chemokines and
is involved in a guinea pig model of asthma. To determine whether eotaxin is a distinctive …

We have isolated genomic and cDNA clones of Brca1, a mouse homolog of the recently
cloned breast cancer-associated gene, BRCA1. Brca1 encodes an 1812-amino-acid protein …

The inbred mouse strain DDK carries a conditional early embryonic lethal mutation that is
manifested when DDK females are crossed to males of other inbred strains but not in the …

The identification of breast cancer susceptibility genes, such as BRCA1, BRCA2, ATM, and
p53, has been accompanied by the examination of the effects of radiation in combination …

We examined the effect of genetic background on Th1/Th2 development. We discuss data
demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) …

Lung cancer, a major cause of death in the Western world, has a poor prognosis1. So far,
therapeutic strategies have had only a limited effect. Lung cancer risk is strongly associated …

Type 1 von Willebrand disease (VWD), characterized by reduced levels of plasma von
Willebrand factor (VWF), is the most common inherited bleeding disorder in humans …

The T-box motif is present in a family of gene whose structural features and expression
patterns support their involvement in developmental gene regulation. Previously, sequence …