ABSTRACT A group of homologous nucleic acid modification enzymes called Dnmt2,
Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a …

The numerous post-transcriptional modifications of tRNA play a crucial role in tRNA function.
While most modifications are introduced to tRNA independently, several sets of …

methylcytosine (m5C) is identified as an abundant and conserved modification in various
RNAs, including tRNAs, mRNAs, rRNAs, and other non-coding RNAs. The application of …

Selective manipulation of the epitranscriptome could be beneficial for the treatment of
cancer and also broaden the understanding of epigenetic inheritance. Inhibitors of the tRNA …

Methylation is a common post-transcriptional modification of tRNAs, particularly in the
anticodon loop region. The cytosine 38 (C38) in tRNAs, such as tRNAAsp-GUC, tRNAGly …

Enzymes of the Dnmt2 family of methyltransferases have yielded a number of unexpected
discoveries. The first surprise came more than ten years ago when it was realized that …

Queuosine is a naturally occurring modified ribonucleoside found in the first position of the
anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to …

ABSTRACT RNA methyltransferase DNMT2/TRDMT1 is the most conserved member of the
DNMT family from bacteria to plants and mammals. In previous studies, we found some …

Dnmt2 methylates cytosine at position 38 of tRNAAsp in a variety of eukaryotic organisms. A
correlation between the presence of the hypermodified nucleoside queuosine (Q) at position …

Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors
such as climate change, extreme poverty, migration, and a lack of life opportunities lead to …