Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

The hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the main cause of two
tightly linked neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and …

Mutation of C9orf72 is the most prevalent defect associated with amyotrophic lateral
sclerosis and frontotemporal degeneration. Together with hexanucleotide-repeat …

While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …

The proper functioning of the cell clearance machinery is critical for neuronal health within
the central nervous system (CNS). In normal physiological conditions, the cell clearance …

Amino acid pools in the cell are monitored by dedicated sensors, whose structures are now
coming into view. The lysosomal Rag GTPases are central to this pathway, and the …

Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating
cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling …