Importance Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns
remain about the potential adverse effects, particularly vascular occlusive events, that may …

Tranexamic acid, a synthetic derivative of the amino acid lysine, is an antifibrinolytic agent
that acts by binding to plasminogen and blocking the interaction of plasmin (ogen) with …

Background context Spine surgery is usually associated with large amount of blood loss,
necessitating blood transfusions. Blood loss-associated morbidity can be because of direct …

Perioperative bleeding and postsurgical hemorrhage are common in invasive surgical
procedures, including orthopedic surgery. Tranexamic acid (TXA) is a pharmacologic agent …

Background Conflicting reports have been published regarding the effect of tranexamic acid
(TXA) on reducing blood loss and transfusion in patients undergoing orthopedic surgery. We …

Background: Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood
loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not …

Purpose The present meta-analysis aimed at assessing the effectiveness and safety of
tranexamic acid (TXA) in reducing blood loss and transfusion in spinal surgery. Methods …

Background. Perioperative tranexamic acid (TXA) use can reduce bleeding and transfusion
requirements in several types of surgery, but level I evidence proving its effectiveness in …

Background Tranexamic acid (TXA) is well-established as a versatile oral, intramuscular,
and intravenous (IV) antifibrinolytic agent. However, the efficacy of IV TXA in reducing …

Purpose Spine surgery is usually associated with large amount of blood loss and blood
transfusion. Excessive blood loss may cause hypotension, inadequate oxygenation of …