Mitochondria have a central role in regulating a range of cellular activities and host
responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and …

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is
dependent on the kinase activity of RIPK1 and RIPK3. Necroptosis leads to rapid plasma …

Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

The coevolution of host-pathogen interactions underlies many human physiological traits
associated with protection from or susceptibility to infections. Among the mechanisms that …

Escherichia coli is a remarkable and diverse organism. This normally harmless commensal
needs only to acquire a combination of mobile genetic elements to become a highly adapted …

Autophagy is emerging as a crucial defense mechanism against bacteria, but the host
intracellular sensors responsible for inducing autophagy in response to bacterial infection …

Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider
mitophagy and related cellular processes and discuss their significance for human disease …

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …