Chagas disease (CD) is one of the most important neglected tropical diseases in the
American continent. Host‐derived nitroxidative stress in response to Trypanosoma cruzi …

The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Redox‐active substances and their combinations, such as of quinone/ascorbate and in
particular menadione/ascorbate (M/A; also named Apatone®), attract attention with their …

Over‐nutrition and its late consequences are a dominant theme in medicine today. In
addition to the health hazards brought on by over‐nutrition, the medical community has …

Naphthoquinones are important natural or synthetic compounds belonging to the general
class of quinones. Many compounds in this class have become drugs that are on the …

Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

Background/Aim: The menadione/ascorbate (M/A) combination has attracted attention due
to the unusual ability of pro-vitamin/vitamin combination to kill cancer cells without affecting …

Background Drugs currently used for the treatment of Chagas' disease, nifurtimox and
benznidazole, have a limited effectiveness and toxic side effects. With the aim of finding new …

Despite many efforts, the currently available treatments for leishmaniasis are not fully
effective. To discover new medications, drug repurposing arises as a promising strategy. We …

Leishmaniasis is a disease caused by hemoflagellate protozoa, affecting millions of people
worldwide. The difficulties of treating patients with this parasitosis include the limited efficacy …