Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Glutamatergic neurons of the mammalian cerebral cortex originate from radial glia (RG)
progenitors in the ventricular zone (VZ). During corticogenesis, neuroblasts migrate toward …

Genetic investigations of people with impaired development of spoken language provide
windows into key aspects of human biology. Over 15 years after FOXP2 was identified, most …

Forebrain neurons have weak intrinsic antioxidant defences compared with astrocytes, but
the molecular basis and purpose of this is poorly understood. We show that early in mouse …

Pax6 is a sequence-specific DNA binding transcription factor that positively and negatively
regulates transcription and is expressed in multiple cell types in the developing and adult …

Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in
learning and memory. Methylation of cytosine nucleotides has historically been considered …

Congenital heart disease (CHD) survivors are at risk for neurodevelopmental disability
(NDD), and recent studies identify genes associated with both disorders, suggesting that …

Cellular differentiation requires dramatic changes in chromatin organization, transcriptional
regulation, and protein production. To understand the regulatory connections between these …

In order to understand whether early epigenetic mechanisms instruct the long-term behavior
of neural stem cells (NSCs) and their progeny, we examined Uhrf1 (ubiquitin-like PHD ring …

The regulation of genome architecture is a key determinant of gene transcription patterns
and neural development. Advances in methodologies based on chromatin conformation …