Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia

RP Hasserjian, DP Steensma… - Blood, The Journal …, 2020 - ashpublications.org
Current objectives regarding treatment of acute myeloid leukemia (AML) include achieving
complete remission (CR) by clinicopathological criteria followed by interrogation for the …

The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting

Y Chen, J Li, L Xu, MA Găman, Z Zou - Cell Death Discovery, 2022 - nature.com
Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic
and genomic alterations. Up to now, combination chemotherapy remains the standard …

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia

AGX Zeng, S Bansal, L Jin, A Mitchell, WC Chen… - Nature medicine, 2022 - nature.com
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

[HTML][HTML] Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission

AH Wei, H Döhner, C Pocock… - … England Journal of …, 2020 - Mass Medical Soc
Background Although induction chemotherapy results in remission in many older patients
with acute myeloid leukemia (AML), relapse is common and overall survival is poor …

MRD tailored therapy in AML: what we have learned so far

LL Ngai, A Kelder, JJWM Janssen… - Frontiers in …, 2021 - frontiersin.org
Acute myeloid leukemia (AML) is a heterogeneous clonal disease associated with a dismal
survival, partly due to the frequent occurrence of relapse. Many patient-and leukemia …

Long noncoding RNAs: a novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia

A Kirtonia, M Ashrafizadeh, A Zarrabi… - Journal of cellular …, 2022 - Wiley Online Library
Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous
nature that resulted from blocked myeloid differentiation and an enhanced number of …

Reproducible measurable residual disease detection by multiparametric flow cytometry in acute myeloid leukemia

MA Röhnert, M Kramer, J Schadt, P Ensel, C Thiede… - Leukemia, 2022 - nature.com
Measurable residual disease (MRD) detected by multiparametric flow cytometry (MFC) is
associated with unfavorable outcome in patients with AML. A simple, broadly applicable …

Measurable residual disease (MRD) as a surrogate efficacy-response biomarker in AML

E Meddi, A Savi, F Moretti, F Mallegni… - International Journal of …, 2023 - mdpi.com
In acute myeloid leukemia (AML) many patients experience relapse, despite the
achievement of morphological complete remission; therefore, conventional morphologic …

Integrating holotomography and deep learning for rapid detection of NPM1 mutations in AML

H Kim, G Kim, HJ Park, MJ Lee, YK Park, S Jang - Scientific Reports, 2024 - nature.com
Rapid and accurate diagnosis of acute myeloid leukemia (AML) remains a significant
challenge, particularly in the context of myelodysplastic syndrome (MDS) or MDS …

Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia

E Aasebø, FS Berven, S Bartaula-Brevik, T Stokowy… - Cancers, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly.
Although complete remission (CR) is achieved for the majority of the patients after induction …