Branched chain amino acids, aging and age-related health

DG Le Couteur, SM Solon-Biet, VC Cogger… - Ageing research …, 2020 - Elsevier
Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …

Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism

ME Trautman, NE Richardson, DW Lamming - Aging cell, 2022 - Wiley Online Library
The proportion of humans suffering from age‐related diseases is increasing around the
world, and creative solutions are needed to promote healthy longevity. Recent work has …

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

CL Green, ME Trautman, K Chaiyakul, R Jain, YH Alam… - Cell Metabolism, 2023 - cell.com
Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …

Effects of branched-chain amino acid–rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: A systematic review and meta-analysis

GH Bai, MC Tsai, WH Hou - Archives of Physical Medicine and …, 2021 - Elsevier
Objectives Protein supplements can improve the loss of muscle in older people. However,
existing reviews have pooled supplements from amino acids to food products together to …

Amino acid nutrition and metabolism in health and disease

AJ Rose - Nutrients, 2019 - mdpi.com
Here an overview of the special issue “Amino acid nutrition and metabolism in health and
disease” is given. In addition to several comprehensive and timely reviews, this issue had …

The degree of hydrolysis and peptide profile affect the anti-fatigue activities of whey protein hydrolysates in promoting energy metabolism in exercise mice

C Zhao, Y Gong, L Zheng, M Zhao - Journal of Agricultural and …, 2023 - ACS Publications
The purpose of this study was to investigate the effects of characteristics of whey protein
hydrolysates (WPHs) on energy metabolism in exercise mice. Results showed that high …

Macronutrient determinants of obesity, insulin resistance and metabolic health

JA Wali, SM Solon-Biet, T Freire, AE Brandon - Biology, 2021 - mdpi.com
Simple Summary Worldwide, overweight and obesity are an ever-increasing problem.
Insulin resistance is often associated with obesity and is a precursor to a range of other …

[HTML][HTML] The regulation of healthspan and lifespan by dietary amino acids

R Babygirija, DW Lamming - Translational medicine of aging, 2021 - Elsevier
As a key macronutrient and source of essential macromolecules, dietary protein plays a
significant role in health. For many years, protein-rich diets have been recommended as …

Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease

MM Sonsalla, DW Lamming - Geroscience, 2023 - Springer
Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …

Dietary branched-chain amino acids intake, glycemic markers, metabolic profile, and anthropometric features in a community-based sample of overweight and obese …

E Soleimani, F Rashnoo, MA Farhangi… - BMC endocrine …, 2023 - Springer
Background Existing research provides conflicting evidence regarding the relationship
between estimated branched-chain amino acid (BCAA) intake and metabolic, glycemic …