A review on advances of treatment modalities for Alzheimer's disease

ES Thoe, A Fauzi, YQ Tang, S Chamyuang, AYY Chia - Life sciences, 2021 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

CA Lemere, E Masliah - Nature Reviews Neurology, 2010 - nature.com
Alzheimer disease (AD) is the most common form of dementia. The amyloid-β (Aβ) peptide
has become a major therapeutic target in AD on the basis of pathological, biochemical and …

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

M Kitazawa, D Cheng, MR Tsukamoto… - The Journal of …, 2011 - journals.aai.org
Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact
on disease progression and neurodegeneration remains an area of active investigation …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo …

B Winblad, N Andreasen, L Minthon… - The Lancet …, 2012 - thelancet.com
Background Immunotherapy targeting the amyloid β (Aβ) peptide is a potential strategy to
slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability …

Engineered nucleic acids and methods of use thereof

S Bancel, JP Schrum, A Aristarkhov - US Patent 9,464,124, 2016 - Google Patents
A61K48/0075—Medicinal preparations containing genetic material which is inserted into
cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of …

Therapeutic approaches to Alzheimer's disease

HW Klafki, M Staufenbiel, J Kornhuber, J Wiltfang - Brain, 2006 - academic.oup.com
Alzheimer's disease is an age-related progressive neurodegenerative disorder with an
enormous unmet medical need. It is the most common form of dementia affecting∼ 5% of …

Aluminum vaccine adjuvants: are they safe?

L Tomljenovic, CA Shaw - Current medicinal chemistry, 2011 - ingentaconnect.com
Aluminum is an experimentally demonstrated neurotoxin and the most commonly used
vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants …

Monoclonal antibodies that target pathological assemblies of Aβ

MP Lambert, PT Velasco, L Chang… - Journal of …, 2007 - Wiley Online Library
Amyloid beta (Aβ) immunotherapy for Alzheimer's disease has shown initial success in
mouse models of Alzheimer's disease and in human patients. However, because of …

Compositions and methods of altering cholesterol levels

SG Hoge, A De Fougerolles, JL Ellsworth - US Patent 8,980,864, 2015 - Google Patents
2014-03-21 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …