In vivo real-time assessment of the histology of diminutive (≤ 5 mm) colorectal polyps
detected at colonoscopy can be achieved by means of an “optical biopsy” by using currently …

In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed
among men and women and the second leading cause of death from cancer. CRC largely …

Background In the National Polyp Study (NPS), colorectal cancer was prevented by
colonoscopic removal of adenomatous polyps. We evaluated the long-term effect of …

Objectives To determine the differences between in-situ, prefixation and postfixation
colorectal polyp measurements, their clinical impact upon determining adenoma …

Background The current practice of removing adenomatous polyps of the colon and rectum
is based on the belief that this will prevent colorectal cancer. To address the hypothesis that …

Polyp size is a critical biomarker for clinical management. Larger polyps have a greater
likelihood of being or of becoming an adenocarcinoma. To balance the referral rate for …

Adenomatous polyps are the most common neoplastic findings discovered in people who
undergo colorectal screening or who have a diagnostic work-up for symptoms. It was …

Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer
chemoprevention trials in place of cancer end points. This paper discusses criteria relevant …

Background Colonoscopy is commonly used to screen for neoplasia. To assess the
performance of screening colonoscopy in everyday practice, we conducted a study of the …

Background: It is widely accepted that the adenoma–carcinoma sequence represents the
process by which most, if not all, colorectal cancers arise. The evidence supporting this …