The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite
mounting evidence to the contrary. Most recent meta-analyses of randomized trials and …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Missing values exist widely in mass-spectrometry (MS) based metabolomics data. Various
methods have been applied for handling missing values, but the selection can significantly …

Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Background The composition of the bile acid (BA) pool is closely associated with obesity
and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition …

BACKGROUND Metabolic syndrome (MetS) is highly correlated with obesity and
cardiovascular risk, but the importance of dietary carbohydrate independent of weight loss in …

Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species
known for its exceptional resistance to spontaneous development of diabetic phenotypes …

Background Intestinal bacteria are known to regulate bile acid (BA) homeostasis via
intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth …

Matrix stiffening and external mechanical stress have been linked to disease and cancer
development in multiple tissues, including the liver, where cirrhosis (which increases …