Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one
of the fastest growing public health problems in the world. It is characterized by …

Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology and target identification and in the evaluation of novel …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is
probably the main form of β-cell death in both forms of the disease. It has been suggested …

Animal models have enormously contributed to the study of diabetes mellitus, a metabolic
disease with abnormal glucose homeostasis, due to some defect in the secretion or the …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD)
and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The …

Objective: The need of today's research is to develop successful and reliable diabetic animal
models for understanding the disease susceptibility and pathogenesis. Enormous success …

Type 1 diabetes mellitus (T1D) is characterized by severe insulin deficiency resulting from
chronic and progressive destruction of pancreatic beta-cells by the immune system. The …

Diabetic disease is increasing rapidly and vast amounts of resources are spent in all
countries. Thus, the screening of new compounds including plant extracts for antidiabetic …