Chronic wasting disease in Europe: new strains on the horizon

MA Tranulis, D Gavier-Widén, J Våge… - Acta Veterinaria …, 2021 - Springer
Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …

Chronic wasting disease: a cervid prion infection looming to spillover

A Otero, CD Velásquez, J Aiken, D McKenzie - Veterinary Research, 2021 - Springer
The spread of chronic wasting disease (CWD) during the last six decades has resulted in
cervid populations of North America where CWD has become enzootic. This insidious …

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice …

J Bian, S Kim, SJ Kane, J Crowell, JL Sun… - Plos …, 2021 - journals.plos.org
Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of
animals and humans. Replication involves template-directed refolding of host encoded prion …

Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease

D Sola, L Tran, J Våge, K Madslien, TT Vuong… - Veterinary …, 2023 - Springer
Prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that
affect several animal species. They are characterized by the conformational conversion of …

The molecular determinants of a universal prion acceptor

H Arshad, Z Patel, ZAM Al-Azzawi, G Amano, L Li… - PLoS …, 2024 - journals.plos.org
In prion diseases, the species barrier limits the transmission of prions from one species to
another. However, cross-species prion transmission is remarkably efficient in bank voles …

Prion strains: shining new light on old concepts

AJ Block, JC Bartz - Cell and Tissue Research, 2023 - Springer
Prion diseases are a group of inevitably fatal neurodegenerative disorders affecting
numerous mammalian species, including humans. The existence of heritable phenotypes of …

Humanized transgenic mice are resistant to chronic wasting disease prions from Norwegian reindeer and moose

JDF Wadsworth, S Joiner, JM Linehan… - The Journal of …, 2022 - academic.oup.com
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion
disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in …

Emergence of CWD strains

A Otero, C Duque Velasquez, D McKenzie… - Cell and Tissue …, 2023 - Springer
Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating
this contagious prion disease of deer, elk, moose, and reindeer. Similar to strains of other …

Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

K Moazami-Goudarzi, O Andréoletti, JL Vilotte… - Veterinary …, 2021 - Springer
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting
several captive, free ranging and wild cervid species. Responsible for marked population …

The Zoonotic Potential of Chronic Wasting Disease—A Review

MA Tranulis, M Tryland - Foods, 2023 - mdpi.com
Prion diseases are transmissible neurodegenerative disorders that affect humans and
ruminant species consumed by humans. Ruminant prion diseases include bovine …