Brain pericytes are perivascular cells that regulate capillary function, and this localization
puts them in a pivotal position for the regulation of central nervous system (CNS) …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Brain pericytes and vascular smooth muscle cells (vSMCs) are a critical component of the
neurovascular unit and are important in regulating cerebral blood flow and blood-brain …

Pericytes (PC) are mural cells that surround endothelial cells in small blood vessels. PC
have traditionally been credited with structural functions, being essential for vessel …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Background Pericytes and endothelial cells are critical cellular components of the blood-
brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of …

The cerebrovasculature is essential to brain health and is tasked with ensuring adequate
delivery of oxygen and metabolic precursors to ensure normal neurologic function. This is …

Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in
treatment and management have significantly improved patient outcomes. On the other …

When modeling disease in the laboratory, it is important to use clinically relevant models.
Patient-derived human brain cells grown in vitro to study and test potential treatments …

Pericyte, a kind of pluripotent cell, may regulate the irrigation flow and permeability of
microcirculation. Pericytes are similar to the smooth muscle cells, which express several …