Background: Metformin toxicity, a challenging clinical entity, is associated with a mortality of
30%. The role of extracorporeal treatments such as hemodialysis is poorly defined at …

In the 1920s, guanidine, the active component of Galega officinalis, was shown to lower
glucose levels and used to synthesize several antidiabetic compounds. Metformin (1, 1 …

Objectives Metformin-associated lactic acidosis (MALA) may occur after acute metformin
overdose, or from therapeutic use in patients with renal compromise. The mortality is high …

Drugs are the most frequent cause of hypoglycaemia in adults. Although hypoglycaemia is a
well known adverse effect of antidiabetic agents, it may occasionally develop in the course …

Therapeutic plasma exchange (TPE) is an extracorporeal process commonly used in clinical
medicine for the treatment of a variety of neurological, renal, hematological, dermatological …

We present the case of a 42‐year‐old female patient who attempted suicide by taking
approximately 100 tablets of metformin (500 mg). Laboratory tests revealed severe lactic …

Metformin is an oral antidiabetic, which is frequently used in the treatment of type II diabetes
mellitus. Serious side effects may be seen during the administration of high doses of …

A 43‐year‐old woman was brought to the hospital with severe metabolic acidosis (pH 6.56,
bicarbonate 3 mmol/L, and lactate 18.4 mmol/L) and a serum creatinine of 162 μmol/L with a …

Metformin (MTF) is a widely used oral antidiabetic medication. Regardless the reason, high
doses of MTF cause lactic acidosis as a result of its effects on mitochondrial ATP production …

Objective: The aim of this study was to evaluate the frequency of metformin-associated lactic
acidosis in our metformin-intoxicated patients, the general approach for their management …