A close look at molecular self-assembly with the transmission electron microscope

A Rizvi, JT Mulvey, BP Carpenter, R Talosig… - Chemical …, 2021 - ACS Publications
Molecular self-assembly is pervasive in the formation of living and synthetic materials.
Knowledge gained from research into the principles of molecular self-assembly drives …

Bioactive electrospun fibers: fabrication strategies and a critical review of surface-sensitive characterization and quantification

MB Taskin, T Ahmad, L Wistlich, L Meinel… - Chemical …, 2021 - ACS Publications
Fabricating a porous scaffold with high surface area has been a major strategy in the tissue
engineering field. Among the many fabrication methods, electrospinning has become one of …

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

RE Veerman, L Teeuwen, P Czarnewski… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are increasingly tested as therapeutic vehicles and biomarkers,
but still EV subtypes are not fully characterised. To isolate EVs with few co‐isolated entities …

[PDF][PDF] Encapsulation state of messenger RNA inside lipid nanoparticles

ML Brader, SJ Williams, JM Banks, WH Hui, ZH Zhou… - Biophysical journal, 2021 - cell.com
Understanding the structure of messenger RNA (mRNA) lipid nanoparticles, and specifically
the microenvironment of the mRNA molecules within these entities, is fundamental to …

Mechanism of efficient double-strand break repair by a long non-coding RNA

R Thapar, JL Wang, M Hammel, R Ye… - Nucleic acids …, 2020 - academic.oup.com
Mechanistic studies in DNA repair have focused on roles of multi-protein DNA complexes,
so how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood. Yet …

Interaction of functionalized nanoparticles with serum proteins and its impact on colloidal stability and cargo leaching

K Abstiens, SM Figueroa, M Gregoritza, AM Goepferich - Soft Matter, 2019 - pubs.rsc.org
The majority of effort in the area of polymeric nanocarriers is aimed at providing controlled
drug delivery in vivo. Therefore, it is essential to understand the delicate interplay of …

[HTML][HTML] Structure determination by single-particle cryo-electron microscopy: only the sky (and intrinsic disorder) is the limit

E Nwanochie, VN Uversky - International journal of molecular sciences, 2019 - mdpi.com
Traditionally, X-ray crystallography and NMR spectroscopy represent major workhorses of
structural biologists, with the lion share of protein structures reported in protein data bank …

[HTML][HTML] Biophysical screening pipeline for cryo-EM grid preparation of membrane proteins

S Niebling, K Veith, B Vollmer, J Lizarrondo… - Frontiers in Molecular …, 2022 - frontiersin.org
Successful sample preparation is the foundation to any structural biology technique.
Membrane proteins are of particular interest as these are important targets for drug design …

[PDF][PDF] Complement in breast milk modifies offspring gut microbiota to promote infant health

D Xu, S Zhou, Y Liu, AL Scott, J Yang, F Wan - Cell, 2024 - cell.com
Breastfeeding offers demonstrable benefits to newborns and infants by providing
nourishment and immune protection and by shaping the gut commensal microbiota …

[HTML][HTML] Changes in membrane protein structural biology

J Birch, H Cheruvara, N Gamage, PJ Harrison, R Lithgo… - Biology, 2020 - mdpi.com
Simple Summary Membrane proteins are essential to all forms of life. Millions of membrane
proteins are found in the lipid membrane layer that surrounds cells, and in the lipid …