Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath

J Park, I Lee, S Jafari, JL Demer - Biomechanics and Modeling in …, 2024 - Springer
We characterized the tensile behavior of sclera, optic nerve (ON), and ON sheath in eyes
from donors with glaucoma, for comparison with published data without glaucoma. Twelve …

Association between ocular diseases and screen time and sedentary time derived from job-exposure matrices

K Sano, K Fukai, R Terauchi, Y Furuya, S Nakazawa… - Scientific Reports, 2024 - nature.com
After developing job-exposure matrices (JEMs) for screen and sedentary time, we aimed to
assess the associations between the JEM-derived exposures and various ocular diseases …

Biomechanics-Function in Glaucoma: Improved Visual Field Predictions from IOP-Induced Neural Strains

T Chuangsuwanich, ME Nongpiur, FA Braeu… - American Journal of …, 2024 - Elsevier
Purpose (1) To assess whether neural tissue structure and biomechanics could predict
functional loss in glaucoma;(2) To evaluate the importance of biomechanics in making such …

Reverse translation of artificial intelligence in glaucoma: Connecting basic science with clinical applications

D Ma, LR Pasquale, MJA Girard, CKS Leung… - Frontiers in …, 2023 - frontiersin.org
Artificial intelligence (AI) has been approved for biomedical research in diverse areas from
bedside clinical studies to benchtop basic scientific research. For ophthalmic research, in …

AI-based clinical assessment of optic nerve head robustness superseding biomechanical testing

FA Braeu, T Chuangsuwanich, TA Tun… - British Journal of …, 2024 - bjo.bmj.com
Background/aims To use artificial intelligence (AI) to:(1) exploit biomechanical knowledge of
the optic nerve head (ONH) from a relatively large population;(2) assess ONH robustness …

[HTML][HTML] The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients

CA Czerpak, MS Kashaf, BK Zimmerman… - … Vision Science & …, 2024 - jov.arvojournals.org
Purpose: The purpose of this study was to measure biomechanical strains in the lamina
cribrosa (LC) of living human eyes undergoing intraocular pressure (IOP) increase …

The association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression

E Kang, JH Park, C Yoo, YY Kim - Graefe's Archive for Clinical and …, 2024 - Springer
Purpose The purpose of this study was to assess the effect of ocular movements on the
progression of glaucoma. Methods A total of 118 primary open-angle glaucoma patients …

Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering

S Lim, C Kim, S Jafari, J Park, SS Garcia, JL Demer - Bioengineering, 2024 - mdpi.com
Postmortem human eyes were subjected to optic nerve (ON) traction in adduction and
elevated intraocular pressure (IOP) to investigate scleral surface deformations. We …

Effects of Stress and Strain on the Optic Nerve Head on the Progression of Glaucoma

E Kang, JH Park, C Yoo, YY Kim - Journal of Glaucoma, 2024 - journals.lww.com
Purpose: We hypothesized that the biomechanical deformation of the optic nerve head
(ONH) contributes to the progression of primary open angle glaucoma (POAG). This study …

Introducing the Biomechanics-Function Relationship in Glaucoma: Improved Visual Field Loss Predictions from intraocular pressure-induced Neural Tissue Strains

T Chuangsuwanich, ME Nongpiur, FA Braeu… - arXiv preprint arXiv …, 2024 - arxiv.org
Objective.(1) To assess whether neural tissue structure and biomechanics could predict
functional loss in glaucoma;(2) To evaluate the importance of biomechanics in making such …