Bio-click chemistry: a bridge between biocatalysis and click chemistry
The fields of click chemistry and biocatalysis have rapidly grown over the last two decades.
The development of robust and active biocatalysts and the widespread use of …
The development of robust and active biocatalysts and the widespread use of …
The Application of Biocatalysis in the Preparation and Resolution of Morita‐Baylis‐Hillman Adducts and Their Derivatives
Abstract The Morita‐Baylis‐Hillman (MBH) reaction affords highly functionalised allylic
alcohols containing a new stereogenic centre. These MBH adducts are very versatile and …
alcohols containing a new stereogenic centre. These MBH adducts are very versatile and …
Chemoenzymatic synthesis of optically active alcohols possessing 1, 2, 3, 4-tetrahydroquinoline moiety employing lipases or variants of the acyltransferase from …
B Zdun, I Kopińska, M Dranka, T Reiter, W Kroutil… - Catalysts, 2022 - mdpi.com
The enzymatic kinetic resolution (EKR) of racemic alcohols or esters is a broadly recognized
methodology for the preparation of these compounds in optically active form. Although EKR …
methodology for the preparation of these compounds in optically active form. Although EKR …
A facile lipase-catalyzed KR approach toward enantiomerically enriched homopropargyl alcohols
P Borowiecki, M Dranka - Bioorganic Chemistry, 2019 - Elsevier
Abstract Compounds possessing propargylic (prop-2-ynylic) system are very important
building blocks for organic chemistry. Among them, preparation of enantiomeric …
building blocks for organic chemistry. Among them, preparation of enantiomeric …
Lipase‐Catalyzed Kinetic Resolution of N‐Substituted 1‐(β‐Hydroxypropyl)indoles by Enantioselective Acetylation
P Borowiecki, M Dranka, Z Ochal - European Journal of …, 2017 - Wiley Online Library
A new, concise, and efficient route towards both antipodes of N‐(β‐hydroxypropyl) indoles is
described. The key step is an enantioselective lipase‐mediated acetylation of racemic …
described. The key step is an enantioselective lipase‐mediated acetylation of racemic …
Design, stereoselective synthesis and computational calculations of novel hybrid compounds via Pauson-Khand reactions
A series of novel chiral hybrid compounds between benzofuran and bicyclic cyclopentenone
and also benzothiophene and bicyclic cyclopentenone have been designed and …
and also benzothiophene and bicyclic cyclopentenone have been designed and …
Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies
D Yenidede, S Gümüş… - Turkish Journal of …, 2016 - journals.tubitak.gov.tr
The one-pot synthesis of novel 1, 4-disubstituted 1, 2, 3-triazoles from isoquinoline-
substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing …
substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing …
[PDF][PDF] Isoquinoline-substituted hybrid compounds: Synthesis and computational studies
The one-pot synthesis of novel 1, 4-disubstituted 1, 2, 3-triazoles from isoquinoline-
substituted homopropargyl alcohol backbone is described (42-88% yields). A ring closing …
substituted homopropargyl alcohol backbone is described (42-88% yields). A ring closing …
[PDF][PDF] Synthesis of Chiral Heteroaryl-Substituted Dihydropyran Derivatives via Ring Closing Enyne Metathesis Reaction
A Gümüş, S Gümüş, NN Büyükadalı, N Aslan - pdfs.semanticscholar.org
The ring closing enyne metathesis reactions have been applied to systems derived from
homopropargylic alcohol backbones are described. The key intermediates 2-benzofuranyl …
homopropargylic alcohol backbones are described. The key intermediates 2-benzofuranyl …
[PDF][PDF] SYNTHESIS AND COMPUTATIONAL CALCULATIONS OF NOVEL CHIRAL BIS-1, 2, 3-TRIAZOLE DERIVATIVES
The one-pot synthesis of novel bis-1, 2, 3-triazole derivatives from homopropargyl alcohol
backbones is described. The key intermediates chiral 2-benzothiophenyl (-)-1 and 2 …
backbones is described. The key intermediates chiral 2-benzothiophenyl (-)-1 and 2 …