Bio-click chemistry: a bridge between biocatalysis and click chemistry

DF Rodríguez, Y Moglie, CA Ramírez-Sarmiento… - RSC …, 2022 - pubs.rsc.org
The fields of click chemistry and biocatalysis have rapidly grown over the last two decades.
The development of robust and active biocatalysts and the widespread use of …

The Application of Biocatalysis in the Preparation and Resolution of Morita‐Baylis‐Hillman Adducts and Their Derivatives

WP Juma, D Nyoni, D Brady, ML Bode - ChemBioChem, 2022 - Wiley Online Library
Abstract The Morita‐Baylis‐Hillman (MBH) reaction affords highly functionalised allylic
alcohols containing a new stereogenic centre. These MBH adducts are very versatile and …

Chemoenzymatic synthesis of optically active alcohols possessing 1, 2, 3, 4-tetrahydroquinoline moiety employing lipases or variants of the acyltransferase from …

B Zdun, I Kopińska, M Dranka, T Reiter, W Kroutil… - Catalysts, 2022 - mdpi.com
The enzymatic kinetic resolution (EKR) of racemic alcohols or esters is a broadly recognized
methodology for the preparation of these compounds in optically active form. Although EKR …

A facile lipase-catalyzed KR approach toward enantiomerically enriched homopropargyl alcohols

P Borowiecki, M Dranka - Bioorganic Chemistry, 2019 - Elsevier
Abstract Compounds possessing propargylic (prop-2-ynylic) system are very important
building blocks for organic chemistry. Among them, preparation of enantiomeric …

Lipase‐Catalyzed Kinetic Resolution of N‐Substituted 1‐(β‐Hydroxypropyl)indoles by Enantioselective Acetylation

P Borowiecki, M Dranka, Z Ochal - European Journal of …, 2017 - Wiley Online Library
A new, concise, and efficient route towards both antipodes of N‐(β‐hydroxypropyl) indoles is
described. The key step is an enantioselective lipase‐mediated acetylation of racemic …

Design, stereoselective synthesis and computational calculations of novel hybrid compounds via Pauson-Khand reactions

S Gümüş, N Aslan, NN Büyükadalı, A Gümüş - Tetrahedron: Asymmetry, 2017 - Elsevier
A series of novel chiral hybrid compounds between benzofuran and bicyclic cyclopentenone
and also benzothiophene and bicyclic cyclopentenone have been designed and …

Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies

D Yenidede, S Gümüş… - Turkish Journal of …, 2016 - journals.tubitak.gov.tr
The one-pot synthesis of novel 1, 4-disubstituted 1, 2, 3-triazoles from isoquinoline-
substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing …

[PDF][PDF] Isoquinoline-substituted hybrid compounds: Synthesis and computational studies

A Gümüş, S Gümüş, D Yenidede, A Gümüş - sciforum.net
The one-pot synthesis of novel 1, 4-disubstituted 1, 2, 3-triazoles from isoquinoline-
substituted homopropargyl alcohol backbone is described (42-88% yields). A ring closing …

[PDF][PDF] Synthesis of Chiral Heteroaryl-Substituted Dihydropyran Derivatives via Ring Closing Enyne Metathesis Reaction

A Gümüş, S Gümüş, NN Büyükadalı, N Aslan - pdfs.semanticscholar.org
The ring closing enyne metathesis reactions have been applied to systems derived from
homopropargylic alcohol backbones are described. The key intermediates 2-benzofuranyl …

[PDF][PDF] SYNTHESIS AND COMPUTATIONAL CALCULATIONS OF NOVEL CHIRAL BIS-1, 2, 3-TRIAZOLE DERIVATIVES

A Gümüş, S Gümüş - Technology, 2017 - academia.edu
The one-pot synthesis of novel bis-1, 2, 3-triazole derivatives from homopropargyl alcohol
backbones is described. The key intermediates chiral 2-benzothiophenyl (-)-1 and 2 …