Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Mechanical forces influence many aspects of cell behaviour. Forces are detected and
transduced into biochemical signals by force-bearing molecular elements located at the cell …

When cells move using integrin-based focal adhesions, they pull in the direction of motion
with large,∼ 100 Pa, stresses that contract the substrate. Integrin-mediated adhesions …

Focal adhesions are large protein complexes organized at the basal surface of cells, which
physically connect the extracellular matrix to the cytoskeleton and have long been …

Cell migration through 3D extracellular matrices is critical to the normal development of
tissues and organs and in disease processes, yet adequate analytical tools to characterize …

The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …

Cell motility plays a critical role in many physiological and pathological settings, ranging
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …

Metastasis involves dissemination of cancer cells away from a primary tumour and
colonization at distal sites. During this process, the mechanical properties of the nucleus …