Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Background Human prion diseases, including Creutzfeldt–Jakob disease (CJD), are rapidly
progressive, invariably fatal neurodegenerative conditions with no effective therapies. Their …

Importance Oligomeric amyloid-β peptide binds to cellular prion protein on the neuronal cell
surface, activating intracellular fyn kinase to mediate synaptotoxicity and tauopathy …

Abstract Background Progression of Alzheimer's disease leads to synapse loss, neural
network dysfunction and cognitive failure. Accumulation of protein aggregates and brain …

Protein phase separation by low-complexity, intrinsically disordered domains generates
membraneless organelles and links to neurodegeneration. Cellular prion protein (PrP C) …

Although amyloid plaques composed of fibrillar amyloid-β (Aβ) assemblies are a diagnostic
hallmark of Alzheimer's disease (AD), quantities of amyloid similar to those in AD patients …

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …

The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …