[HTML][HTML] Macrophages in health and disease
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …
increasingly transparent over the last decade. But with the plethora of data comes a natural …
The role of goblet cells and mucus in intestinal homeostasis
JK Gustafsson, MEV Johansson - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …
[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …
[HTML][HTML] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
The metabolic nature of inflammatory bowel diseases
TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …
[HTML][HTML] IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
M Friedrich, M Pohin, MA Jackson, I Korsunsky… - Nature Medicine, 2021 - nature.com
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …
[HTML][HTML] Molecular pathways of colon inflammation induced by cancer immunotherapy
Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …
can induce durable responses in a wide range of human cancers. However, the …
[HTML][HTML] Confronting false discoveries in single-cell differential expression
Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …
type-specific responses to perturbations such as disease, trauma, or experimental …
[HTML][HTML] Cells of the human intestinal tract mapped across space and time
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …
utero and changing in response to functional requirements and environmental exposures …
[HTML][HTML] A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics
J Burclaff, RJ Bliton, KA Breau, MT Ok… - Cellular and molecular …, 2022 - Elsevier
Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …
function at the cellular level, yet studies analyzing healthy adult human small intestine and …