[HTML][HTML] Macrophages in health and disease

MD Park, A Silvin, F Ginhoux, M Merad - Cell, 2022 - cell.com
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

The role of goblet cells and mucus in intestinal homeostasis

JK Gustafsson, MEV Johansson - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

[HTML][HTML] Spatially organized multicellular immune hubs in human colorectal cancer

K Pelka, M Hofree, JH Chen, S Sarkizova, JD Pirl… - Cell, 2021 - cell.com
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors …

[HTML][HTML] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

The metabolic nature of inflammatory bowel diseases

TE Adolph, M Meyer, J Schwärzler, L Mayr… - Nature Reviews …, 2022 - nature.com
Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

[HTML][HTML] IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

M Friedrich, M Pohin, MA Jackson, I Korsunsky… - Nature Medicine, 2021 - nature.com
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …

[HTML][HTML] Molecular pathways of colon inflammation induced by cancer immunotherapy

AM Luoma, S Suo, HL Williams, T Sharova, K Sullivan… - Cell, 2020 - cell.com
Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …

[HTML][HTML] Confronting false discoveries in single-cell differential expression

JW Squair, M Gautier, C Kathe, MA Anderson… - Nature …, 2021 - nature.com
Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …

[HTML][HTML] Cells of the human intestinal tract mapped across space and time

R Elmentaite, N Kumasaka, K Roberts, A Fleming… - Nature, 2021 - nature.com
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

[HTML][HTML] A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics

J Burclaff, RJ Bliton, KA Breau, MT Ok… - Cellular and molecular …, 2022 - Elsevier
Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …