R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …

During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …

Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …

R-loop, a three-stranded RNA/DNA structure, has been linked to induced genome instability
and regulated gene expression. To enable precision analysis of R-loops in vivo, we develop …

In eukaryotes, three-dimensional genome organization is critical for transcriptional
regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin …

The past decade has seen a major increase in the study of noncoding RNAs (ncRNAs).
However, there remains a great deal of confusion and debate over the levels of functionality …

Several neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and
spinocerebellar ataxia (SCA) are caused by non‐coding nucleotide repeat expansions …