Local anesthetic systemic toxicity (LAST) is a life-threatening adverse event that may occur
after the administration of local anesthetic drugs through a variety of routes. Increasing use …

The classic description of local anesthetic systemic toxicity (LAST) generally described in
textbooks includes a series of progressively worsening neurologic symptoms and signs …

The currently available local anaesthetic agents are capable of providing high quality nerve
blockade in a wide variety of clinical circumstances. Our understanding of the mechanisms …

Two new, long-acting local anaesthetics have been developed after the evidence of
bupivacaine-related severe toxicity: levobupivacaine and ropivacaine. Both these agents …

In recent years levobupivacaine, the pure S (−)-enantiomer of bupivacaine, emerged as a
safer alternative for regional anesthesia than its racemic parent. It demonstrated less affinity …

Lipid emulsion has been used in the successful treatment of local anaesthetic‐induced
cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous …

Résumé Objectif La pratique de l'anesthesie regionale a recemment vecu un second souffle
graˆce ala popularite croissante des techniques echoguidees. Les defenseurs de ces …

Purpose Regional anesthesia is enjoying a renaissance due in part to the advent of
ultrasound guidance and the development of new techniques such as tissue plane blocks …

Compared with bupivacaine, both agents may be considered as 'more well tolerated'but not
as 'totally well tolerated', as they are still capable of inducing systemic and local toxicity …

The American Society of Regional Anesthesia and Pain Medicine introduced an intensive
workshop focused on lower-extremity peripheral nerve blockade in 2002. This review is the …