In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

This paper is the third in a series of reviews published in this issue resulting from the
University of California Davis Cardiovascular Symposium 2014: Systems approach to …

Rationale: In heart failure (HF), impaired sarcoplasmic reticulum (SR) Ca2+ release and
cytosolic Na+ overload depress mitochondrial Ca2+ (mCa2+) signaling, resulting in a …

Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …

Rationale: In cardiomyocytes from failing hearts, insufficient mitochondrial Ca2+
accumulation secondary to cytoplasmic Na+ overload decreases NAD (P) H/NAD (P)+ redox …

Cardiac glycosides, the cardiotonic steroids such as digitalis have been in use as heart
ailment remedy since ages. They manipulate the renin-angiotensin axis to improve cardiac …

In this review, we summarize our knowledge about mitochondrial potassium channels, with
a special focus on unanswered questions in this field. The following potassium channels …

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety
of disorders including cancer, diabetes, and neurodegenerative and cardiovascular …