Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Lactate, once considered a waste product of glycolysis, has emerged as a critical regulator
of cancer development, maintenance, and metastasis. Indeed, tumor lactate levels correlate …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Although there has been a renewed interest in the field of cancer metabolism in the last
decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be …

The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

During cancer progression, cancer cells are repeatedly exposed to metabolic stress
conditions in a resource-limited environment which they must escape. Increasing evidence …

The p53‐inducible TIGAR protein functions as a fructose‐2, 6‐bisphosphatase, promoting
the pentose phosphate pathway and helping to lower intracellular reactive oxygen species …

Regulation of glucose metabolism is a crucial aspect of cell physiology in normal and
disease conditions. Many regulatory events are involved in determining the metabolic fate of …

Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …

The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator)
functions as a fructose-2, 6-bisphosphatase (Fru-2, 6-BPase), and through promotion of the …