Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Fluorine incorporation is ideally suited to many NMR techniques, and incorporation of
fluorine into proteins and fragment libraries for drug discovery has become increasingly …

A key challenge in bioconjugation is to control the site selectivity of the reaction. Chemical
reagents often react with proteineous chemical groups without showing preference to their …

Intracellular signaling from receptor tyrosine kinases (RTK) on extracellular stimulation is
fundamental to all cellular processes. The protein–protein interactions which form the basis …

The recognition of PPxY viral Late domains by the third WW domain of the HECT-E3
ubiquitin ligase NEDD4 (hNEDD4-WW3) is essential for the completion of the budding …

Abstract Development of effective inhibitors of the fusion between HIV-1 and the host cell
membrane mediated by gp41 continues to be a grand challenge due to an incomplete …

The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10
regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such …

The recognition of PPxY viral Late domains by the third WW domain of the human HECT-E3
ubiquitin ligase NEDD4 (NEDD4-WW3) is essential for the budding of many viruses …

Accurate evaluation of protein–ligand binding free energies in silico is of paramount
importance for understanding the mechanisms of biological regulation and providing a …