The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Timing chemotherapy on the basis of the body's intrinsic circadian clock—ie,
chronomodulated chemotherapy—might improve efficacy and reduce treatment toxicity. This …

Circadian clock proteins are endogenous timing mechanisms that control the transcription of
hundreds of genes. Their integral role in coordinating metabolism has led to their scrutiny in …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive,
and cognitive signaling processes, playing an important role in homeostasis and …

Personalized medicine strives to deliver the 'right drug at the right dose'by considering inter-
person variability, one of the causes for therapeutic failure in specialized populations of …

The circadian timing system (CTS) controls various biological functions in mammals
including xenobiotic metabolism and detoxification, immune functions, cell cycle events …

Circadian rhythms,≈ 24 h oscillations in behavior and physiology, are reflected in all cells of
the body and function to optimize cellular functions and meet environmental challenges …

Circadian rhythms are a collection of endogenously driven biochemical, physiological, and
behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues …