T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
CD45 in human physiology and clinical medicine
A Rheinländer, B Schraven, U Bommhardt - Immunology letters, 2018 - Elsevier
CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …
Multiple signaling roles of CD3ε and its application in CAR-T cell therapy
W Wu, Q Zhou, T Masubuchi, X Shi, H Li, X Xu… - Cell, 2020 - cell.com
AT cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ,
γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative …
γ, and ζ, but the contributions of different CD3 chains remain elusive. Using quantitative …
The genomic landscape of hypodiploid acute lymphoblastic leukemia
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …
T cell receptor signalling networks: branched, diversified and bounded
RJ Brownlie, R Zamoyska - Nature Reviews Immunology, 2013 - nature.com
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
EH Palacios, A Weiss - Oncogene, 2004 - nature.com
The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …
studied over the past 15 years. Animal models and cell line studies both indicate a critical …
Localized effects of cAMP mediated by distinct routes of protein kinase A
K Taskén, EM Aandahl - Physiological reviews, 2004 - journals.physiology.org
Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
Getting under the skin: the immunogenetics of psoriasis
AM Bowcock, JG Krueger - Nature Reviews Immunology, 2005 - nature.com
Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T cells, dendritic
cells and inflammatory cytokines. We now understand many of the cellular alterations that …
cells and inflammatory cytokines. We now understand many of the cellular alterations that …
Molecular mechanisms for cAMP-mediated immunoregulation in T cells–role of anchored protein kinase a signaling units
VL Wehbi, K Taskén - Frontiers in immunology, 2016 - frontiersin.org
The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target …
Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease
N Bottini, EJ Peterson - Annual review of immunology, 2014 - annualreviews.org
Inheritance of a coding variant of the protein tyrosine phosphatase nonreceptor type 22
(PTPN22) gene is associated with increased susceptibility to autoimmunity and infection …
(PTPN22) gene is associated with increased susceptibility to autoimmunity and infection …