Imaging biomarkers for clinical applications in neuro-oncology: current status and future perspectives

FY Chiu, Y Yen - Biomarker Research, 2023 - Springer
Biomarker discovery and development are popular for detecting the subtle diseases.
However, biomarkers are needed to be validated and approved, and even fewer are ever …

The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications

SM Faisal, A Comba, ML Varela, AE Argento… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a
poor prognosis due to its universal recurrence rate. GBM cells interact with the non-cellular …

Alternative normalization and analysis pipeline to address systematic bias in NanoString GeoMx Digital Spatial Profiling data

L van Hijfte, M Geurts, WR Vallentgoed, PHC Eilers… - Iscience, 2023 - cell.com
Spatial transcriptomics is a novel technique that provides RNA-expression data with tissue-
contextual annotations. Quality assessments of such techniques using end-user generated …

Mechanical properties in the glioma microenvironment: emerging insights and theranostic opportunities

AG Bhargav, JS Domino, R Chamoun… - Frontiers in …, 2022 - frontiersin.org
Gliomas represent the most common malignant primary brain tumors, and a high-grade
subset of these tumors including glioblastoma are particularly refractory to current standard …

Histone deacetylase inhibitors impair glioblastoma cell motility and proliferation

E Rampazzo, L Manfreda, S Bresolin, A Cani… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is considered the deadliest brain tumor; with patients
displaying a high incidence of relapse and a 3-year survival of only 3–5%. For these …

A generalizable strategy for crosslinkable albumin-based hydrogels and application as potential anti-tumor nanoplatform

WW Lv, K Yang, J Yu, Y Wu, M Zhang… - Journal of …, 2023 - journals.sagepub.com
Albumin-based hydrogels have emerged as promising nanoparticle systems for the effective
delivery of hydrophobic anticancer drugs. Anti-cancer drugs often cause some adverse …

Nanoparticle-Based Treatment in Glioblastoma

D Roque, N Cruz, HA Ferreira, CP Reis… - Journal of Personalized …, 2023 - mdpi.com
Glioblastoma (GB) is a malignant glioma associated with a mean overall survival of 12 to 18
months, even with optimal treatment, due to its high relapse rate and treatment resistance …

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities

A Karz, M Dimitrova, K Kleffman… - Pigment cell & …, 2022 - Wiley Online Library
Brain metastases are the most common brain malignancy. This review discusses the studies
presented at the third annual meeting of the Melanoma Research Foundation in the context …

Spatiotemporal insights into glioma oncostream dynamics: unraveling formation, stability, and disassembly pathways

SM Faisal, JE Clewner, B Stack, ML Varela… - Advanced …, 2024 - Wiley Online Library
Glioblastoma (GBM) remains a challenge in Neuro‐oncology, with a poor prognosis
showing only a 5% survival rate beyond two years. This is primarily due to its …

Role of nerves in neurofibromatosis type 1-related nervous system tumors

LL Ge, MY Xing, HB Zhang, QF Li, ZC Wang - Cellular Oncology, 2022 - Springer
Abstract Background Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic
disorder that affects nearly 1 in 3000 infants. Neurofibromin inactivation and N F1 gene …