Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms

SA Dingsdag, N Hunter - Journal of Antimicrobial …, 2018 - academic.oup.com
Metronidazole, a nitroimidazole, remains a front-line choice for treatment of infections
related to inflammatory disorders of the gastrointestinal tract including colitis linked to …

Biochemistry and evolution of anaerobic energy metabolism in eukaryotes

M Müller, M Mentel, JJ van Hellemond… - Microbiology and …, 2012 - Am Soc Microbiol
Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

D Leitsch - Parasitology, 2019 - cambridge.org
The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …

[HTML][HTML] Trichomoniasis-are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?

CB Menezes, AP Frasson, T Tasca - Microbial cell, 2016 - ncbi.nlm.nih.gov
Etiology: Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common
non-viral sexually transmitted disease (STD) in the world. Transmission: Trichomoniasis is …

Nitroimidazoles: molecular fireworks that combat a broad spectrum of infectious diseases

CW Ang, AM Jarrad, MA Cooper… - Journal of medicinal …, 2017 - ACS Publications
Infectious diseases claim millions of lives every year, but with the advent of drug resistance,
therapeutic options to treat infections are inadequate. There is now an urgent need to …

Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis

T Edwards, P Burke, H Smalley… - Critical reviews in …, 2016 - Taylor & Francis
Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral
sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health …

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

R Argüello-García, D Leitsch, T Skinner-Adams… - Advances in …, 2020 - Elsevier
The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

Drug Resistance in the Microaerophilic Parasite Giardia lamblia

D Leitsch - Current tropical medicine reports, 2015 - Springer
The microaerophilic parasite Giardia lamblia is a causative agent of dysentery affecting
hundreds of millions of people around the globe every year. The symptoms of the disease …

Drug resistance in Giardia duodenalis

BRE Ansell, MJ McConville, SY Ma'ayeh… - Biotechnology …, 2015 - Elsevier
Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a
major contributor to diarrheal and post-infectious chronic gastrointestinal disease world …

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

A Trochine, DJ Creek, P Faral-Tello… - PLoS neglected …, 2014 - journals.plos.org
Background The first line treatment for Chagas disease, a neglected tropical disease caused
by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole …