Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is
lower than normal for a person's age, but a higher function than that that observed in a …

Brain aging is closely related to neurodegenerative diseases. Circular RNAs (circRNAs) are
a type of conserved RNAs with covalently closed continuous loops. Emerging evidence has …

Introduction: The importance of neurodegenerative diseases on the management of public
health is growing and the real role of the environment and miRNA in their occurrence is still …

A general hallmark of neurological diseases is the loss of redox homeostasis that triggers
oxidative damages to biomolecules compromising neuronal function. Under physiological …

Gene expression in the aging brain depends on transcription signals generated by
senescent physiology, interacting with genetic and epigenetic programs. In turn …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has
not only resulted in a dramatic decrease in the peripheral viral load but has also led to …

Aging is a major risk factor for many human diseases, including cognitive impairment, which
affects a large population of the elderly. In the past few decades, our understanding of the …

Epigenetics is emerging as the missing link among genetic inheritance, environmental
influences, and body and brain health status. In the brain, specific changes in nucleic acids …

Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases.
Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and …