A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors

AR Patten, CJ Fontaine, BR Christie - Frontiers in pediatrics, 2014 - frontiersin.org
Prenatal ethanol exposure (PNEE) has been linked to widespread impairments in brain
structure and function. There are a number of animal models that are used to study the …

Review of rodent models of attention deficit hyperactivity disorder

SL Regan, MT Williams, CV Vorhees - Neuroscience & Biobehavioral …, 2022 - Elsevier
Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder
that affects 8–12% of children and> 4% of adults. Environmental factors are believed to …

The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: Insights from rodent models

K Marquardt, JL Brigman - Alcohol, 2016 - Elsevier
Abstract Fetal Alcohol Spectrum Disorders (FASD) are characterized by deficits in working
memory, response inhibition, and behavioral flexibility. However, the combination and …

Persistent impairment of hippocampal neurogenesis in young adult rats following early postnatal alcohol exposure

AY Klintsova, JL Helfer, LH Calizo… - Alcoholism: Clinical …, 2007 - Wiley Online Library
Background: Prenatal alcohol exposure can cause damage to the developing fetus with
outcomes including growth deficiency, facial dysmorphology, brain damage, and cognitive …

Voluntary exercise rescues deficits in spatial memory and long‐term potentiation in prenatal ethanol‐exposed male rats

BR Christie, SE Swann, CJ Fox, D Froc… - European journal of …, 2005 - Wiley Online Library
Prenatal ethanol exposure can lead to long‐lasting impairments in the ability to process
spatial information in rats, as well as produce long‐lasting deficits in the ability of animals to …

Effects of prenatal exposure to alcohol on activity, anxiety, motor coordination, and memory in young adult Wistar rats

I Dursun, E Jakubowska-Doğru, T Uzbay - Pharmacology Biochemistry and …, 2006 - Elsevier
The objective of the present study was to examine the effects of prenatal exposure to ethanol
on motor performance, emotionality, learning and memory in young-adult, male Wistar rats …

Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing …

S Subbanna, NN Nagre, NS Umapathy… - International Journal …, 2015 - academic.oup.com
Background: Ethanol exposure to rodents during postnatal day 7 (P7), which is comparable
to the third trimester of human pregnancy, induces long-term potentiation and memory …

Fetal alcohol spectrum disorders and abnormal neuronal plasticity

AE Medina - The Neuroscientist, 2011 - journals.sagepub.com
The ingestion of alcohol during pregnancy can result in a group of neurobehavioral
abnormalities collectively known as fetal alcohol spectrum disorders (FASD). During the past …

Selective and enduring deficits in spatial learning after limited neonatal binge alcohol exposure in male rats

TB Johnson, CR Goodlett - Alcoholism: Clinical and …, 2002 - Wiley Online Library
Background: In rats, heavy bingelike alcohol exposure during the neonatal brain growth
spurt [postnatal days (PD) 4–9] can impair development of spatial learning. This study tested …

Postnatal ethanol exposure activates HDAC-mediated histone deacetylation, impairs synaptic plasticity gene expression and behavior in mice

M Shivakumar, S Subbanna, V Joshi… - International Journal …, 2020 - academic.oup.com
Background Alcohol consumption during pregnancy is widespread and contributes to
pediatric neurological defects, including hippocampal and neocortex dysfunction, causing …