Specific expression and functions of circular RNAs
In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by
their covalently closed circular structure, have become a new research paradigm in RNA …
their covalently closed circular structure, have become a new research paradigm in RNA …
CircRNAs: a regulator of cellular stress
JW Fischer, AKL Leung - Critical reviews in biochemistry and …, 2017 - Taylor & Francis
Abstract Circular RNAs (CircRNAs) were first identified as a viroid and later found to also be
an endogenous RNA splicing product in eukaryotes. In recent years, a series of RNA …
an endogenous RNA splicing product in eukaryotes. In recent years, a series of RNA …
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Abstract Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of
adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic …
adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic …
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
TL Wong, JJ Loh, S Lu, HHN Yan, HC Siu, R Xi… - Nature …, 2023 - nature.com
Targetable drivers governing 5-fluorouracil and cisplatin (5FU+ CDDP) resistance remain
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger
J Devoldere, H Dewitte, SC De Smedt, K Remaut - Drug discovery today, 2016 - Elsevier
Highlights•We review the immune-related hurdles in mRNA-based non-immunogenic
applications.•We suggest some methods to reduce unwanted innate immune …
applications.•We suggest some methods to reduce unwanted innate immune …
Post-transcriptional regulation of homeostatic, stressed, and malignant stem cells
Cellular identity is not driven by differences in genomic content but rather by epigenomic,
transcriptomic, and proteomic heterogeneity. Although regulation of the epigenome plays a …
transcriptomic, and proteomic heterogeneity. Although regulation of the epigenome plays a …
Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin …
Cancer initiating cells (CICs) are responsible for the unrestrained cell growth and
chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial …
chemoresistance of malignant tumors. Histone demethylation has been shown to be crucial …
ADAR1 prevents autoinflammatory processes in the heart mediated by IRF7
C Garcia-Gonzalez, C Dieterich, G Maroli… - Circulation …, 2022 - Am Heart Assoc
Background: ADAR1 (adenosine deaminase acting on RNA-1)-mediated adenosine to
inosine (A-to-I) RNA editing plays an essential role for distinguishing endogenous from …
inosine (A-to-I) RNA editing plays an essential role for distinguishing endogenous from …
Circular RNA biogenesis is decreased in postmortem cortical gray matter in schizophrenia and may alter the bioavailability of associated miRNA
E Mahmoudi, C Fitzsimmons, MP Geaghan… - …, 2019 - nature.com
Circular RNAs (circRNAs) are a covalently closed subclass of non-coding RNA molecules
formed by back splicing of linear precursor RNA. These molecules are relatively stable and …
formed by back splicing of linear precursor RNA. These molecules are relatively stable and …
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation
X Liu, Y Fu, J Huang, M Wu, Z Zhang, R Xu… - Journal of Experimental …, 2019 - Springer
Background Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-
inosine (A-to-I) editing and implicated in tumorigenesis and prognosis. Emerging evidence …
inosine (A-to-I) editing and implicated in tumorigenesis and prognosis. Emerging evidence …