Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

SH Wong, J Yu - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

Fusobacterium nucleatum — symbiont, opportunist and oncobacterium

CA Brennan, WS Garrett - Nature Reviews Microbiology, 2019 - nature.com
Fusobacterium nucleatum has long been found to cause opportunistic infections and has
recently been implicated in colorectal cancer; however, it is a common member of the oral …

The human gut microbiome–a potential controller of wellness and disease

ZY Kho, SK Lal - Frontiers in microbiology, 2018 - frontiersin.org
Interest toward the human microbiome, particularly gut microbiome has flourished in recent
decades owing to the rapidly advancing sequence-based screening and humanized …

Role of oral microbiota in cancer development

TM Karpiński - Microorganisms, 2019 - mdpi.com
Nowadays cancer is the second main cause of death in the world. The most known bacterial
carcinogen is Helicobacter pylori. Pathogens that can have an impact on cancer …

Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System

J Abed, N Maalouf, AL Manson, AM Earl… - Frontiers in cellular …, 2020 - frontiersin.org
Fusobacterium nucleatum is a common oral bacterium that is enriched in colorectal
adenomas and adenocarcinomas (CRC). In humans, high fusobacterial CRC abundance is …

Fusobacterium nucleatum and oral cancer: a critical review

E McIlvanna, GJ Linden, SG Craig, FT Lundy… - BMC cancer, 2021 - Springer
There is a growing level of interest in the potential role inflammation has on the initiation and
progression of malignancy. Notable examples include Helicobacter pylori-mediated …

Microbiome in colorectal cancer: how to get from meta-omics to mechanism?

D Ternes, J Karta, M Tsenkova, P Wilmes, S Haan… - Trends in …, 2020 - cell.com
Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

H Pandey, DWT Tang, SH Wong, D Lal - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

MA Engevik, HA Danhof, W Ruan, AC Engevik… - MBio, 2021 - Am Soc Microbiol
Multiple studies have implicated microbes in the development of inflammation, but the
mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in …

Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality

S Wang, Y Liu, J Li, L Zhao, W Yan, B Lin… - Frontiers in Cell and …, 2021 - frontiersin.org
Colorectal cancer (CRC) is a common cancer worldwide with complex etiology.
Fusobacterium nucleatum (F. nucleatum), an oral symbiotic bacterium, has been linked with …