The role of the il-6 cytokine family in epithelial–mesenchymal plasticity in cancer progression
A Abaurrea, AM Araujo, MM Caffarel - International journal of molecular …, 2021 - mdpi.com
Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development,
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …
[HTML][HTML] Interplay between tumor microenvironment and partial EMT as the driver of tumor progression
Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has
been extensively studied to address the unresolved variable treatment response across …
been extensively studied to address the unresolved variable treatment response across …
Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer
G Malagoli Tagliazucchi, AJ Wiecek, E Withnell… - Nature …, 2023 - nature.com
The epithelial to mesenchymal transition (EMT) is a key cellular process underlying cancer
progression, with multiple intermediate states whose molecular hallmarks remain poorly …
progression, with multiple intermediate states whose molecular hallmarks remain poorly …
A theoretical approach to coupling the epithelial-mesenchymal transition (EMT) to extracellular matrix (ECM) stiffness via LOXL2
Simple Summary Epithelial-mesenchymal transition (EMT) is a key process in cancer
progression through which cells weaken their cell-cell adhesion and gain mobility and …
progression through which cells weaken their cell-cell adhesion and gain mobility and …
Landscape and kinetic path quantify critical transitions in epithelial-mesenchymal transition
Abstract Epithelial-mesenchymal transition (EMT), a basic developmental process that might
promote cancer metastasis, has been studied from various perspectives. Recently, the early …
promote cancer metastasis, has been studied from various perspectives. Recently, the early …
Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma
Drug resistance and tumor relapse in patients with melanoma is attributed to a combination
of genetic and non-genetic mechanisms. Dedifferentiation, a common mechanism of non …
of genetic and non-genetic mechanisms. Dedifferentiation, a common mechanism of non …
Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma
Phenotypic (ie non-genetic) heterogeneity in melanoma drives dedifferentiation,
recalcitrance to targeted therapy and immunotherapy, and consequent tumor relapse and …
recalcitrance to targeted therapy and immunotherapy, and consequent tumor relapse and …
[HTML][HTML] Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT
Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial
transition (MET) are central to metastatic aggressiveness and therapy resistance in solid …
transition (MET) are central to metastatic aggressiveness and therapy resistance in solid …
Inference of intercellular communications and multilayer gene-regulations of epithelial–mesenchymal transition from single-cell transcriptomic data
Epithelial-to-mesenchymal transition (EMT) plays an important role in many biological
processes during development and cancer. The advent of single-cell transcriptome …
processes during development and cancer. The advent of single-cell transcriptome …
Involvement of epithelial–mesenchymal transition genes in small cell lung cancer phenotypic plasticity
Simple Summary Small cell lung cancer (SCLC) is an aggressive cancer that is difficult to
treat. There are at least five subtypes of SCLC cells, defined by gene expression signatures …
treat. There are at least five subtypes of SCLC cells, defined by gene expression signatures …