Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …

B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

Purpose: Hans and coworkers previously developed an immunohistochemical algorithm
with∼ 80% concordance with the gene expression profiling (GEP) classification of diffuse …

Hashimoto's thyroiditis (HT) is the most common autoimmune disease characterized by
lymphocytic infiltration and thyrocyte destruction. Dissection of the interaction between the …

Serpins are a broadly distributed family of protease inhibitors that use a conformational
change to inhibit target enzymes. They are central in controlling many important proteolytic …

Gene expression profiling (GEP) has stratified diffuse large B-cell lymphoma (DLBCL) into
molecular subgroups that correspond to different stages of lymphocyte development …

Immunological memory is the residuum of a successful immune response that in the B cell
lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that …

The superfamily of serine proteinase inhibitors (serpins) are involved in a number of
fundamental biological processes such as blood coagulation, complement activation …

We have analyzed the blood B cell subpopulations of children with systemic lupus
erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B …

Somatic hypermutation (SHM) in the variable region of immunoglobulin genes (IGV)
naturally occurs in a narrow window of B cell development to provide high-affinity …