1, 3, 4-thiadiazole scaffold: As anti-epileptic agents

T Anthwal, S Nain - Frontiers in Chemistry, 2022 - frontiersin.org
A wide range of biological activities is exhibited by 1, 3, 4-thiadiazole moiety such as
antidiabetic, anticancer, anti-inflammatory, anticonvulsant, antiviral, antihypertensive, and …

1, 3, 4-thiadiazole scaffold: Anti-microbial agents

T Anthwal, HO Singh, S Nain - Pharmaceutical Chemistry Journal, 2022 - Springer
1, 3, 4-Thiadiazole moiety has various biological activities including anticancer, antidiabetic,
antihypertensive, anti-inflammatory, antiviral, and anti-microbial. Some drugs with …

New N-(1,3,4-thiadiazole-2-yl)acetamide derivatives as human carbonic anhydrase I and II and acetylcholinesterase inhibitors

S Dawbaa, C Türkeş, D Nuha, Y Demir… - Journal of …, 2024 - Taylor & Francis
Various carbonic anhydrase (CA) enzyme isoforms are known today. In addition to the use
of CA inhibitors as diuretics, antiepileptics and antiglaucoma agents, the inhibition of other …

New N-alkylated heterocyclic compounds as prospective NDM1 inhibitors: Investigation of in vitro and in silico properties

Y Kaddouri, B Bouchal, F Abrigach, M El Kodadi… - Pharmaceuticals, 2022 - mdpi.com
A new family of pyrazole-based compounds (1–15) was synthesized and characterized
using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C NMR, and …

New 1, 3, 4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

Z Ali, W Rehman, L Rasheed, AY Alzahrani, N Ali… - ACS …, 2024 - ACS Publications
Diabetes is an emerging disorder in the world and is caused due to the imbalance of insulin
production as well as serious effects on the body. In search of a better treatment for diabetes …

Synthesis, characterization, and antioxidant activities of new 1, 3, 4-thiadiazoles based on benzoic acid

H Yakan - El-Cezeri, 2021 - dergipark.org.tr
N-aryl-1, 3, 4-thiadiazole derivatives were obtained by cyclization reaction of benzoic acid
and N-arylthiosemicarbazides in the presence of phosphorous oxychloride (POCl3). FT-IR …

Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of 1,3,4-Thiadiazole Derivatives of 3-Aminopyridin-2(1H)-ones

Z Shulgau, IV Palamarchuk, S Sergazy, A Urazbayeva… - Pharmaceuticals, 2024 - mdpi.com
This article reports on the synthesis of nine promising new 1, 3, 4-thiadiazole derivatives
based on 3-aminopyridones, containing various acidic linkers. The synthesis was carried out …

Microwave‐Assisted Synthesis and Characterization of Some Aldehyde Derivatives of Imidazo [2, 1‐b][1, 3, 4] thiadiazole: Crystal Structure Insights, In‐Silico and …

KS Sagar, K Kumara, B SH, NK Lokanath… - …, 2023 - Wiley Online Library
The microwave‐assisted synthesis, crystallographic studies, in‐silico docking and the
evaluation of in‐vitro biological activities of 2‐(3, 4‐dimethoxy)‐6‐(substituted phenyl) …

1, 3, 4-Thiadiazole: A Versatile Scaffold for Drug Discovery

RK Mittal, R Mishra, V Sharma… - Letters in Organic …, 2024 - ingentaconnect.com
1, 3, 4-Thiadiazole has garnered considerable attention in the scientific community due to its
captivating molecular structure and ability to serve as a foundation for creating novel …

Significance of Molecular Docking in Developing Potent Antimicrobial 1, 3, 4-Thiadiazole Derivatives

P Kaur, V Arora - Letters in Organic Chemistry, 2023 - benthamdirect.com
New drug development has been a convoluted, costly, tedious, and difficult job. Overall,
enormous sums of money are required for a new drug development pipeline through …